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Dipl.-Ing. S. Mülhopt

Dipl.-Ing. S. Mülhopt
 
Phone ++49(0)721/608-23807
eMail: sonja muelhoptSil5∂kit edu

Partner:
  • VITROCELL Systems GmbH
  • EU-Konsortium NanoMILE, coordinator: University of Birmingham
  • Helmholtz Zentrum München
  • University of Cardiff (Mülhopt et al., 2015)
  • University of Eastern Finland
  • University of Luxembourg
  • University of Rostock
  • Technical University of Munich 
  • Max Delbrück Center for Molecular Medicine 
  • Deutsches Biomasseforschungszentrum DBFZ
  • Institut für Feuerungs- und Kraftwerkstechnik, Universität Stuttgart
  • Naturwissenschaftliches und Medizinische Institut Reutlingen, NMI
  • Technologieforschungszentrum Straubing

Department Aerosols and Particles

Exposure Systems

 

Research interests:

 

  • Development of  the Karlsruhe Exposure Systems for the deposition of nanoparticles to cell cultures
     
  • Measurement of deposition rate of nanoparticles to surfaces by Quartz Crystal  Microbalance (QCM)
     
  • Application of the Karlsruhe Exposure System for the assessment of toxicity of combustion aerosols
     
  • Measurement of size distributions of nanoparticles  
     

Recent publications and patents:

 

  • Kanashova T, Sippula O, Oeder S, Streibel T, Passig J, Czech H, Kaoma T, Sapcariu SC, Dilger M, Paur H-R, Schlager C, Mülhopt S, Weiss C, Schmidt-Weber C, Traidl-Hoffmann C, Michalke B, Krebs T, Karg E, Jakobi G, Scholtes S, Schnelle-Kreis J, Sklorz M, Orasche J, Müller L, Reda A, Rüger C, Neumann A, Abbaszade G, Radischat C, Hiller K, Grigonyte J, Kortelainen M, Kuuspalo K, Lamberg H, Leskinen J, Nuutinen I, Torvela T, Tissari J, Javala P, Kasurinen S, Uski O, Hirvonen M-R, Buters J, Dittmar G, Jokiniemi J, Zimmermann R. (2018). Emissions from a Modern Log wood Masonry Heater and Wood Pellet Boiler: Composition and Biological Impact on Air-Liquid Interface Exposed Human Lung Cancer Cells. Journal of Molecular and Clinical Medicine 1(1):23–35.
     
  • Langevin D, Lozano O, Salvati A, Kestens V, Monopoli M, Raspaud E, Mariot S, Salonen A, Thomas S, Driessen M, Haase A, Nelissen I, Smisdom N, Pompa PP, Maiorano G, Puntes V, Puchowicz D, Stępnik M, Suárez G, Riediker M, Benetti F, Mičetić I, Venturini M, Kreyling WG, van der Zande M, Bouwmeester H, Milani S, Rädler JO, Mülhopt S, Lynch I, Dawson K. (2018). Inter-laboratory comparison of nanoparticle size measurements using dynamic light scattering and differential centrifugal sedimentation. Nanoimpact 10:97–107.
     
  • Krebs, T., Mülhopt, S., Diabaté, S., Schlager, C., Paur, H.-R., Dilger, M. (2017). In Vitro Exposure Systems to Access the Toxicity of Airborne Substances. Biomedical Application of Nanoparticles. Ed.: B. H. Rihn. Verlag CRC Press. Chapter 9, 1 - 14. ISBN: 978-1-4987-5001-1
     
  • Sapcariu, S. C., Kanashova, T., Dilger, M., Diabaté, S., Oeder, S., Passig, J., Radischat, C., Buters, J., Sippula, O., Streibel, T., Paur, H.-R., Schlager C., Mülhopt, S., Stengel, B., Rabe, R., Harndorf, H., Krebs, T., Karg, E., Gröger, T., Weiss, C., Dittmer, G., Hiller, K., Zimmermann, R. (2016). Metabolic Profiling as Well as Stable Isotope Assisted Metabolic and Proteomic Analysis of RAW 264.7 Macrophages Exposed to Ship Engine Aerosol  Emissions: Different Effects of Heavy Fuel Oil and Refined Diesel Fuel. PLoS one, 11(6), e0157964. DOI: 10.1371/journal.pone.0157964, ISSN: 1932-6203.
     
  • Mülhopt, S., Paur, H.-R., Schlager, C. (2016). Vorrichtung zur Messung von Feinstpartikelmassen. Patent DE 10 2014 118 846 B4
     
  • Mülhopt, S., Dilger, M., Diabaté, S., Schlager, C., Krebs, T., Zimmermann, R., Buters, J., Oeder, S., Wäscher, T., Weiss, C., & Paur, H.-R. (2016). Toxicity testing of combustion aerosols at the air-liquid interface with a self-contained and easy-to-use exposure system. Journal of Aerosol Science, 96, 18. doi: http://dx.doi.org/10.1016/j.jaerosci.2016.02.005
     
  • Dilger, M., Orasche, J., Zimmermann, R., Paur, H.-R., Diabaté, S., & Weiss, C. (2016). Toxicity of wood smoke particles in human A549 lung epithelial cells: the role of PAHs, soot and zinc. Archives of Toxicology, 1-16. doi: 10.1007/s00204-016-1659-1
     
  • Mülhopt, S., Diabate, S., Schlager, C., Dilger, M., Krebs, T., Weiss, C., & Paur, H.-R. (2015). Automatisierte und definierte Deposition von Aerosolen auf Zellkulturen für eine Bewertung der biologischen Wirksamkeit von Feinstäuben. In V. W. GmbH (Ed.), Neue Entwicklungen bei der Messung und Beurteilung der Luftqualität (Vol. 2250, pp. 243-247). Düsseldorf: VDI Verlag GmbH.
     
  • Mülhopt, S., Krebs, T., Diabaté, S., Schlager, C., & Paur, H.-R. (2015). Feinstaub in der Lunge - Automatisiertes Expositionssystem für Zellkulturen an der Gas-Flüssigkeits-Grenzschicht. labor&more, 02/15, 32-37. http://www.laborundmore.com/research/6468,804272/Sonja-Muelhopt/Automatisiertes-Expositionssystem-fuer-Zellkulturen-an-der-Gas-Fluessigkeits-Grenzschicht.html 
     
  • Oeder, S., Kanashova, T., Sippula, O., Sapcariu, S. C., Streibel, T., Arteaga-Salas, J. M., Passig, J., Dilger, M., Paur, H.-R., Schlager, C., Mülhopt, S., Diabaté, S., Weiss, C., Stengel, B., Rabe, R., Harndorf, H., Torvela, T., Jokiniemi, J. K., Hirvonen, M.-R., Schmidt-Weber, C., Traidl-Hoffmann, C., BéruBé, K. A., Wlodarczyk, A. J., Prytherch, Z., Michalke, B., Krebs, T., Prévôt, A. S. H., Kelbg, M., Tiggesbäumker, J., Karg, E., Jakobi, G., Scholtes, S., Schnelle-Kreis, J., Lintelmann, J., Matuschek, G., Sklorz, M., Klingbeil, S., Orasche, J., Richthammer, P., Müller, L., Elsasser, M., Reda, A., Gröger, T., Weggler, B., Schwemer, T., Czech, H., Rüger, C. P., Abbaszade, G., Radischat, C., Hiller, K., Buters, J. T. M., Dittmar, G., & Zimmermann, R. (2015). Particulate Matter from Both Heavy Fuel Oil and Diesel Fuel Shipping Emissions Show Strong Biological Effects on Human Lung Cells at Realistic and Comparable In Vitro Exposure Conditions. PLOS ONE, 10(6), e0126536. doi: 10.1371/journal.pone.0126536
     
  • Panas, A., Comouth, A., Saathoff, H., Leisner, T., Al-Rawi, M., Simon, M., Seemann, G., Dössel, O., Mülhopt, S., Paur, H.-R., Fritsch-Decker, S., Weiss, C., & Diabaté, S. (2014). Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure. Beilstein Journal of Nanotechnology, 5, 1590-1602. doi: 10.3762/bjnano.5.171
     
  • Paur, H.-R., Cassee, F. R., Teeguarden, J., Fissan, H., Diabate, S., Aufderheide, M., Kreyling, W. G., Hänninen, O., Kasper, G., Riediker, M., Rothen-Rutishauser, B., & Schmid, O. (2011). In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung-A dialog between aerosol science and biology. Journal of Aerosol Science, 42, 668-692. doi: 10.1016/j.jaerosci.2011.06.005
     
  • Comouth, A., Saathoff, H., Naumann, K.-H., Mülhopt, S., Paur, H.-R., & Leisner, T. (2013). Modelling and measurement of particle deposition for cell exposure at the air liquid interface. Journal of Aerosol Science, 63, 103-114. doi: 10.1016/j.jaerosci.2013.04.009
     
  • Panas, A., Marquardt, C., Nalcaci, O., Bockhorn, H., Baumann, W., Paur, H.-R., Mülhopt, S., Diabaté, S., & Weiss, C. (2013). Screening of different metal oxide nanoparticles reveals selective toxicity and inflammatory potential of silica nanoparticles in lung epithelial cells and macrophages. Nanotoxicology, 7(3), 259-273. doi: 10.3109/17435390.2011.652206